![]() Greenberg PL, Attar E, Bennett JM, et al. National Heart, Lung, and Blood Institute. ![]() Environmental factors, lifestyle risk factors, and host characteristics associated with Philadelphia negative myeloproliferative neoplasm: A systematic review. These tests are not typically part of the diagnosis of myeloproliferative disorders, but they can be helpful during the diagnostic process or when complications occur.Īllahverdi N, Yassin M, Ibrahim M. Imaging tests: Tests such as X-rays and computed tomography (CT) scans can sometimes detect signs of bone marrow abnormalities.Genetic test: A genetic test can identify mutations that are associated with specific myeloproliferative disorders.They are both safe procedures and can be uncomfortable, but the discomfort resolves quickly after the procedure. A bone marrow biopsy is a similar procedure that involves a larger sample. Bone marrow aspiration or biopsy: A bone marrow aspiration is a sample of bone marrow tissue that is obtained with a needle and examined microscopically.Blood smear: A blood sample can be examined microscopically to identify specific blood cell changes.This test is usually part of a routine medical checkup, and it is also often done to evaluate symptoms such as fatigue and feeling sick. Complete blood count (CBC): This blood test detects the number of blood cells including platelets, red blood cells, and different types of white blood cells.The condition is slowly progressive and may progress to AML. Chronic neutrophilic leukemia: Liver and spleen enlargement, weight loss, fevers, sore throat, bruising, and bone pain can occur.Chronic eosinophilic leukemia: It can cause itching, cough, muscle pain, or diarrhea.This is a type of cancer that can cause other blood cell types to be low, and the myeloid cells may spread throughout the blood. Chronic myelogenous leukemia: Bleeding, bone pain, weight loss, night sweats, and fevers can occur.Primary myelofibrosis: Effects can include an enlarged spleen, weight loss, shortness of breath, night sweats, anemia (low red blood cells), bleeding, and blood clots.It can cause serious problems, including stroke (in which blood flow is blocked to part of the brain) and heart attack (in which blood flow is blocked to the heart muscle), and it may rarely progress to myelofibrosis or AML. Essential thrombocythemia: Headaches, dizziness, skin rash, numbness, fainting, chest pain, and bleeding are the common symptoms.It can lead to acute myelogenous leukemia (AML)-a serious type of blood cancer-or myelofibrosis ( bone marrow cancer). Polycythemia vera: This may cause dizziness, itchiness, enlarged spleen (which appears as a swollen abdomen), bleeding and bruising, blood clots, bone pain, or shortness of breath.
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